Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 4/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39728 | 0.87 | BRAF (0.46) | KDM4ECCR1MLYCDBRAFROCK2 | |
| SCHEMBL39746 | 0.86 | KDM4E (0.47) | KDM4ECCR1MLYCDBRAFROCK2 | |
| SCHEMBL19595916 | 0.84 | BRAF (0.48) | KDM4EMLYCDBRAFROCK2CHRM3 | |
| SCHEMBL39772 | 0.82 | SERPINE1 (0.47) | KDM4ECCR1MLYCDBRAFROCK2 | |
| SCHEMBL39989 | 0.82 | SLC34A2 (0.47) | KDM4EBRAFRAF1MEN1PLA2G1B | |
| SCHEMBL40086 | 0.82 | SERPINE1 (0.47) | KDM4ECCR1MLYCDBRAFROCK2 | |
| SCHEMBL39860 | 0.81 | SLC34A2 (0.53) | KDM4EMLYCDBRAFROCK2CHRM3 | |
| SCHEMBL6000691 | 0.81 | SLC34A2 (0.49) | KDM4EMLYCDBRAFROCK2CHRM3 | |
| SCHEMBL16355250 | 0.81 | SLC34A2 (0.51) | KDM4EBRAFROCK2RAF1HRH4 | |
| SCHEMBL15432502 | 0.81 | SLC34A2 (0.52) | KDM4EMLYCDBRAFROCK2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |