Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 7/20 | 0.51 |
| ▸ | GUCY1B1 | Q02153 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3996498 | 0.93 | KEAP1 (0.45) | GUCY1A1GUCY1B1MEN1KMT2AMRGPRX4 | |
| SCHEMBL3998293 | 0.87 | KEAP1 (0.46) | GUCY1A1GUCY1B1MEN1KMT2AMRGPRX4 | |
| SCHEMBL3994735 | 0.83 | GUCY1A1 (0.52) | GUCY1A1GUCY1B1HPGDKDM4EL3MBTL1 | |
| SCHEMBL3998343 | 0.81 | GUCY1A1 (0.58) | GUCY1A1GUCY1B1HPGDKDM4EL3MBTL1 | |
| SCHEMBL3998943 | 0.80 | GUCY1B2 (0.43) | GUCY1A1GUCY1B1MAPTGAACYP2C9 | |
| SCHEMBL3998243 | 0.80 | KEAP1 (0.49) | GUCY1A1GUCY1B1MEN1KMT2AKEAP1 | |
| SCHEMBL3997533 | 0.80 | GUCY1A1 (0.56) | GUCY1A1GUCY1B1HPGDKDM4EL3MBTL1 | |
| SCHEMBL1783451 | 0.80 | GUCY1A1 (0.61) | GUCY1A1GUCY1B1HPGDKDM4EL3MBTL1 | |
| SCHEMBL3997119 | 0.80 | GUCY1A1 (0.56) | GUCY1A1GUCY1B1HPGDKDM4EL3MBTL1 | |
| SCHEMBL3997024 | 0.79 | GUCY1A1 (0.51) | GUCY1A1GUCY1B1HPGDKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |