Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 19/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4000144 | 0.80 | HTR2C (0.36) | SLC6A4HRH3 | |
| SCHEMBL11641906 | 0.72 | SLC6A4 (0.71) | SLC6A4SLC6A2SLC6A3HRH3 | |
| SCHEMBL1572964 | 0.72 | SLC6A4 (0.70) | SLC6A4SLC6A2SLC6A3HRH3 | |
| Hydrochloric Acid SCHEMBL1573224 | 0.71 | SLC6A4 (0.69) | SLC6A4SLC6A2SLC6A3HRH3 | |
| SCHEMBL11638679 | 0.70 | SLC6A4 (1.00) | SLC6A4SLC6A2SLC6A3HRH3 | |
| Hydrochloric Acid SCHEMBL11805015 | 0.69 | SLC6A4 (0.74) | SLC6A4SLC6A2SLC6A3HRH3 | |
| SCHEMBL5249197 | 0.69 | SLC6A4 (1.00) | SLC6A4SLC6A2SLC6A3HRH3 | |
| SCHEMBL11792580 | 0.68 | SLC6A4 (0.76) | SLC6A4SLC6A2SLC6A3HRH3 | |
| Hydrochloric Acid SCHEMBL11798250 | 0.68 | SLC6A4 (0.75) | SLC6A4SLC6A2SLC6A3HRH3 | |
| SCHEMBL4003091 | 0.68 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009005459-A1 | PHENYL-1,2, 3,4-TETRAHYDROISOQUINOLINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF A PAIN DISORDER | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | WO | claimed |
| WO-2009005459-A1 | PHENYL-1,2, 3,4-TETRAHYDROISOQUINOLINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF A PAIN DISORDER | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | WO | disclosed |