Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.58 |
| ▸ | IKBKB | O14920 | 10/20 | 0.57 |
| ▸ | CHUK | O15111 | 10/20 | 0.57 |
| ▸ | IKBKG | Q9Y6K9 | 10/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008028 | 0.99 | BTK (0.57) | BTKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL4003732 | 0.92 | BTK (0.56) | BTKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL3996324 | 0.92 | BTK (0.70) | BTKCDK2CDK1CDK9PLK4 | |
| SCHEMBL4987511 | 0.91 | BTK (0.55) | BTKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL4000789 | 0.91 | BTK (0.55) | BTKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL4002612 | 0.90 | BTK (0.55) | BTKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL4985527 | 0.89 | BTK (0.53) | BTKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL4000801 | 0.89 | BTK (0.57) | BTKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL4003456 | 0.88 | BTK (0.56) | BTKIKBKBCHUKIKBKGMTOR | |
| SCHEMBL4983305 | 0.86 | BRD4 (0.48) | BTKIKBKBCHUKIKBKGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069314-A1 | PYRIMIDINES DERIVATIVES AND THEIR USE AS KINASE INHIBITORS | CGI Pharmaceuticals, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| US-20080125417-A1 | CERTAIN PYRIMIDINES, METHOD OF MAKING, AND METHOD OF USE THEREOF | CGI PHARMACEUTICALS, INC. | 2008-05-29 | — | — | US | disclosed |
| WO-2008033834-A1 | PYRIMIDINES DERIVATIVES AND THEIR USE AS KINASE INHIBITORS | CGI PHARMACEUTICALS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125417-A1 | CERTAIN PYRIMIDINES, METHOD OF MAKING, AND METHOD OF USE THEREOF | BTK, SYK, TK1 | BTK 1/4885IKBKB 104/4885CHUK 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.