Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | USP7 | Q93009 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4002141 | 0.85 | KMT2A (0.40) | KMT2AMEN1ALDH1A1GAARECQL | |
| SCHEMBL3998063 | 0.83 | GRM5 (0.49) | ALDH1A1CYP2D6 | |
| SCHEMBL4289367 | 0.83 | CYP3A4 (0.40) | KMT2AMEN1ALDH1A1GAACYP3A4 | |
| SCHEMBL5668375 | 0.82 | MEN1 (0.45) | KMT2AMEN1ALDH1A1TSHRLMNA | |
| SCHEMBL5666899 | 0.82 | SMN1; SMN2 (0.51) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL5667080 | 0.81 | LMNA (0.49) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL5668605 | 0.80 | MEN1 (0.46) | KMT2AMEN1ALDH1A1KDM4ETSHR | |
| SCHEMBL3999620 | 0.80 | MAPK1 (0.46) | KMT2AMEN1ALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL4003459 | 0.79 | CYP2C9 (0.56) | KMT2AMEN1ALDH1A1KDM4ECYP2C9 | |
| SCHEMBL2938912 | 0.78 | CYP3A4 (0.42) | KMT2AMEN1ALDH1A1GAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095402-A9 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | GRUENENTHAL GMBH (DE) | 2009-06-11 | — | — | WO | claimed |
| EP-1730147-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4,5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | Grünenthal GmbH (DE) | 2006-12-13 | — | — | EP | claimed |
| WO-2005095402-A1 | SUBSTITUTED 1,4,8-TRIAZASPIRO[4.5]DECAN-2-ON COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | Grünenthal GmbH (DE) | 2005-10-13 | — | — | WO | claimed |