Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 13/20 | 0.81 |
| ▸ | SLC6A5 | Q9Y345 | 6/20 | 0.59 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4002174 | 1.00 | SLC6A9 (0.81) | SLC6A9SLC6A5GPR139KDM4EHDAC8 | |
| SCHEMBL2009265 | 0.89 | SLC6A9 (1.00) | SLC6A9SLC6A5GPR139HTTL3MBTL1 | |
| SCHEMBL2008251 | 0.86 | SLC6A9 (0.94) | SLC6A9SLC6A5GPR139HTTL3MBTL1 | |
| SCHEMBL2013065 | 0.83 | SLC6A9 (0.88) | SLC6A9SLC6A5GPR139HTTL3MBTL1 | |
| SCHEMBL2005249 | 0.82 | SLC6A9 (0.87) | SLC6A9SLC6A5GPR139KDM4EHTT | |
| SCHEMBL2008680 | 0.82 | SLC6A9 (0.85) | SLC6A9SLC6A5GPR139 | |
| SCHEMBL2007906 | 0.82 | SLC6A9 (0.85) | SLC6A9SLC6A5GPR139 | |
| SCHEMBL2009566 | 0.79 | SLC6A9 (0.80) | SLC6A9SLC6A5GPR139ALDH1A1 | |
| SCHEMBL2011839 | 0.79 | SLC6A9 (0.80) | SLC6A9SLC6A5GPR139ALDH1A1 | |
| SCHEMBL2011783 | 0.79 | SLC6A9 (0.67) | SLC6A9SLC6A5GPR139HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066620-A1 | DI-AROMATIC SUBSTITUTED AMIDES AS INHIBITORS FOR GLYT1 | F. Hoffmann-Roche AG (CH) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008022938-A1 | DI-AROMATIC SUBSTITUTED AMIDES AS INHIBITORS FOR GLYT1 | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-28 | — | — | WO | disclosed |