Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.44 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.42 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.42 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4002703 | 0.84 | MEN1 (0.42) | TLR7KCNN1KCNN2KCNN3LMNA | |
| SCHEMBL4739125 | 0.72 | GSK3B (0.51) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL5353533 | 0.72 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL6017115 | 0.70 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL2348949 | 0.70 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL6512906 | 0.69 | PDE4A (0.86) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL9029366 | 0.68 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL5563021 | 0.68 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL4029525 | 0.68 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL5555670 | 0.68 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009074677-A2 | PYRAZOLOTRIAZINES | 4SC AG (DE) | 2009-06-18 | — | — | WO | disclosed |
| EP-2070932-A1 | Pyrazolotriazines | 4SC AG (DE) | 2009-06-17 | — | — | EP | disclosed |