Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.86 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.86 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.86 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.86 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5561428 | 0.85 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL2348949 | 0.84 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL14367275 | 0.84 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL5555670 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL18292422 | 0.80 | ENPP2 (0.72) | PDE4APDE4BPDE4CPDE4DRXFP1 | |
| SCHEMBL4092061 | 0.79 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL5563021 | 0.79 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL4074953 | 0.78 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL6518180 | 0.78 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL5353533 | 0.77 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050203110-A1 | Mitotic kinesin inhibitors | COLEMAN PAUL J (US) | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203110-A1 | Mitotic kinesin inhibitors | KIF2C, KIF5B, KIF18B | PDE4A 1969/4885PDE4B 2199/4885PDE4C 2049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.