Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914406 | 0.72 | MEN1 (0.41) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL5264043 | 0.70 | DHODH (0.47) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL3926834 | 0.69 | LMNA (0.39) | KMT2AMEN1HTTALDH1A1LMNA | |
| SCHEMBL2228112 | 0.68 | AURKA (0.59) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL3922575 | 0.68 | LMNA (0.50) | KMT2AMEN1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5914227 | 0.64 | MEN1 (0.43) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL24444297 | 0.63 | EGLN3 (0.46) | KMT2AMEN1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3923592 | 0.63 | DPP4 (0.37) | ALDH1A1SMN1; SMN2NPSR1KDRMAPT | |
| SCHEMBL5314182 | 0.62 | MEN1 (0.42) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL23579969 | 0.62 | CYP11B1 (0.42) | LMNAKDRADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041118-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007114827-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-10-11 | — | — | WO | disclosed |