Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 13/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003466 | 1.00 | HSD11B1 (0.56) | HSD11B1EPHX2KMT2ATSHRPOLB | |
| SCHEMBL4009615 | 0.85 | HSD11B1 (0.56) | HSD11B1EPHX2KMT2ATSHRPOLB | |
| SCHEMBL4009624 | 0.85 | HSD11B1 (0.56) | HSD11B1EPHX2KMT2ATSHRPOLB | |
| SCHEMBL4006942 | 0.85 | EPHX2 (0.60) | HSD11B1EPHX2KMT2A | |
| SCHEMBL4006937 | 0.85 | EPHX2 (0.60) | HSD11B1EPHX2KMT2A | |
| SCHEMBL4143730 | 0.83 | EPHX2 (0.78) | HSD11B1EPHX2KMT2ATSHRPOLB | |
| SCHEMBL4145741 | 0.82 | HSD11B1 (0.72) | HSD11B1EPHX2KMT2ATSHRPOLB | |
| SCHEMBL4287004 | 0.82 | EPHX2 (0.79) | EPHX2KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL4439394 | 0.81 | EPHX2 (0.78) | HSD11B1EPHX2KMT2ATSHR | |
| SCHEMBL4290150 | 0.81 | EPHX2 (0.78) | HSD11B1EPHX2KMT2ATSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |