Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4006018 | 1.00 | ROCK2 (0.35) | ROCK2LIMK1CHEK1MAPK8MAPK10 | |
| SCHEMBL5072945 | 0.93 | CHRNA7 (0.36) | ROCK2LIMK1CHEK1NPC1MAPT | |
| SCHEMBL4006505 | 0.93 | CHRNA7 (0.36) | ROCK2LIMK1CHEK1NPC1MAPT | |
| SCHEMBL4012585 | 0.81 | CHRNA7 (0.34) | ROCK2LIMK1CHEK1MAPK8MAPK10 | |
| SCHEMBL4012614 | 0.79 | ROCK2 (0.37) | ROCK2LIMK1CHEK1MAPK8MAPK10 | |
| SCHEMBL4011639 | 0.78 | NPC1 (0.37) | ROCK2LIMK1CHEK1MAPK8MAPK10 | |
| SCHEMBL4003549 | 0.78 | NPC1 (0.37) | ROCK2LIMK1CHEK1MAPK8MAPK10 | |
| SCHEMBL4012717 | 0.77 | ROCK2 (0.36) | ROCK2LIMK1CHEK1MAPK8MAPK10 | |
| SCHEMBL4012401 | 0.77 | ROCK2 (0.36) | ROCK2LIMK1CHEK1MAPK8MAPK10 | |
| SCHEMBL4006519 | 0.77 | ROCK2 (0.34) | ROCK2LIMK1CHEK1MAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765327-A4 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1959960-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007070683-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |
| EP-1765327-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006009726-A2 | SUBSTITUTED UREA DERIVATIVES FOR TREATING CARDIAC DISEASES | CYTOKINETICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |