Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 11/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003547 | 0.90 | HDAC1 (0.54) | MAPK14CYP2C9HDAC1RIPK2 | |
| SCHEMBL4002899 | 0.84 | MAPK14 (0.57) | MAPK14CYP2C9RIPK2 | |
| SCHEMBL4143741 | 0.79 | NPC1 (0.59) | MAPK14CYP2C9RIPK2SMN1; SMN2 | |
| SCHEMBL4007396 | 0.79 | MAPK14 (0.60) | MAPK14CYP2C9RIPK2 | |
| SCHEMBL4006648 | 0.78 | MAPK14 (0.56) | MAPK14CYP2C9RIPK2 | |
| SCHEMBL3093442 | 0.75 | MAPK14 (0.77) | MAPK14CYP2C9RIPK2 | |
| SCHEMBL4005132 | 0.75 | MAPK14 (0.59) | MAPK14RIPK2 | |
| SCHEMBL4003836 | 0.73 | MAPK14 (0.55) | MAPK14CYP2C9RIPK2 | |
| SCHEMBL4007418 | 0.72 | MAPK14 (0.51) | MAPK14CYP2C9RIPK2 | |
| SCHEMBL4003034 | 0.72 | MAPK14 (0.68) | MAPK14CYP2C9RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009078992-A1 | LINEAR TRICYCLIC COMPOUNDS AS P38 KINASE INHIBITORS | AMGEN INC. (US) | 2009-06-25 | — | — | WO | claimed |
| WO-2009078992-A1 | LINEAR TRICYCLIC COMPOUNDS AS P38 KINASE INHIBITORS | AMGEN INC. (US) | 2009-06-25 | — | — | WO | disclosed |
| WO-2009078992-A1 | LINEAR TRICYCLIC COMPOUNDS AS P38 KINASE INHIBITORS | AMGEN INC. (US) | 2009-06-25 | — | — | WO | disclosed |