Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 11/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4007396 | 0.85 | MAPK14 (0.60) | CYP2C9MAPK14RIPK2 | |
| SCHEMBL4002899 | 0.85 | MAPK14 (0.57) | CYP2C9MAPK14RIPK2 | |
| SCHEMBL4006648 | 0.84 | MAPK14 (0.56) | CYP2C9MAPK14RIPK2 | |
| SCHEMBL4003640 | 0.79 | MAPK14 (0.53) | CYP2C9MAPK14SMN1; SMN2RIPK2 | |
| SCHEMBL14326940 | 0.77 | MAPK14 (0.74) | CYP2C9MAPK14RIPK2 | |
| SCHEMBL4003034 | 0.77 | MAPK14 (0.68) | CYP2C9MAPK14RIPK2 | |
| SCHEMBL4003547 | 0.76 | HDAC1 (0.54) | CYP2C9MAPK14RIPK2 | |
| SCHEMBL3093442 | 0.76 | MAPK14 (0.77) | CYP2C9MAPK14RIPK2 | |
| SCHEMBL3079711 | 0.76 | MAPK14 (0.70) | CYP2C9MAPK14RIPK2 | |
| SCHEMBL4003836 | 0.75 | MAPK14 (0.55) | CYP2C9MAPK14RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009078992-A1 | LINEAR TRICYCLIC COMPOUNDS AS P38 KINASE INHIBITORS | AMGEN INC. (US) | 2009-06-25 | — | — | WO | disclosed |
| WO-2009078992-A1 | LINEAR TRICYCLIC COMPOUNDS AS P38 KINASE INHIBITORS | AMGEN INC. (US) | 2009-06-25 | — | — | WO | disclosed |