Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003843 | 0.84 | KMT2A (0.46) | SMN1; SMN2HTTKMT2ATSHRHPGD | |
| SCHEMBL3759007 | 0.80 | HTT (0.48) | SMN1; SMN2HTTKMT2ATSHRUSP2 | |
| SCHEMBL3759227 | 0.80 | HTT (0.40) | SMN1; SMN2HTTKMT2AHPGDMEN1 | |
| SCHEMBL3756638 | 0.78 | KMT2A (0.41) | SMN1; SMN2HTTKMT2ATSHRHPGD | |
| SCHEMBL3761663 | 0.78 | KMT2A (0.49) | SMN1; SMN2HTTKMT2ATSHRUSP2 | |
| SCHEMBL3765037 | 0.72 | SIGMAR1 (0.47) | SMN1; SMN2HTTKMT2ATSHRUSP2 | |
| SCHEMBL3756655 | 0.70 | HTT (0.48) | SMN1; SMN2HTTKMT2ATSHRHPGD | |
| SCHEMBL3758808 | 0.68 | TSHR (0.50) | SMN1; SMN2HTTKMT2ATSHRHPGD | |
| SCHEMBL3760043 | 0.68 | SMN1; SMN2 (0.44) | SMN1; SMN2HTTKMT2ATSHRUSP2 | |
| SCHEMBL3765086 | 0.67 | TSHR (0.49) | SMN1; SMN2HTTKMT2ATSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071895-A1 | FUSED THIAZOLE AND THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-06-11 | — | — | WO | disclosed |