Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 5/20 | 0.32 |
| ▸ | CHUK | O15111 | 5/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | BTK | Q06187 | 2/20 | 0.31 |
| ▸ | ITK | Q08881 | 2/20 | 0.31 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3923592 | 0.79 | DPP4 (0.37) | KDRDPP4IKBKBCHUK | |
| SCHEMBL3924760 | 0.79 | HRH4 (0.43) | KDRDPP4CDK2 | |
| SCHEMBL5947912 | 0.78 | DPP4 (0.35) | DPP4IKBKBCHUK | |
| SCHEMBL3935077 | 0.75 | MAP3K5 (0.41) | KDRCYP3A4CYP2D6DPP4CDK2 | |
| SCHEMBL5948011 | 0.74 | CCNE1 (0.48) | CDK2ITK | |
| SCHEMBL3924645 | 0.73 | CCNE2 (0.45) | KDRIKBKBCHUKCDK2 | |
| SCHEMBL3927808 | 0.73 | NPC1 (0.36) | KDRCYP3A4CYP2D6DPP4CDK2 | |
| SCHEMBL3924389 | 0.73 | MAPK8 (0.40) | KDRCYP3A4CDK2 | |
| SCHEMBL3924707 | 0.72 | MKNK1 (0.45) | KDRCYP3A4CYP2D6CDK2 | |
| SCHEMBL3922932 | 0.71 | KDR (0.39) | KDRCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041118-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007114827-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-10-11 | — | — | WO | disclosed |