Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 17/20 | 0.48 |
| ▸ | CDK2 | P24941 | 17/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 14/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 14/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 14/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924389 | 0.87 | MAPK8 (0.40) | CCNE1CDK2CCNE2CCNA2CCNA1 | |
| SCHEMBL14396494 | 0.83 | MAPK8 (0.40) | CCNE1CDK2CCNE2CCNA2CCNA1 | |
| SCHEMBL5948116 | 0.82 | USP30 (0.44) | PIM1PIM2 | |
| SCHEMBL3924645 | 0.80 | CCNE2 (0.45) | CCNE1CDK2CCNE2CCNA2CCNA1 | |
| SCHEMBL3924760 | 0.79 | HRH4 (0.43) | CCNE1CDK2CCNE2CCNA2CCNA1 | |
| SCHEMBL3935077 | 0.77 | MAP3K5 (0.41) | CCNE1CDK2CCNE2CCNA2CCNA1 | |
| SCHEMBL3933938 | 0.76 | GRIN2B (0.41) | CCNE1CDK2CCNE2CCNA2CCNA1 | |
| SCHEMBL3923646 | 0.76 | VCP (0.35) | CCNE1CDK2CCNE2CCNA2CCNA1 | |
| SCHEMBL3923592 | 0.76 | DPP4 (0.37) | MAPK13FGFR1MAPK1AKT1AKT2 | |
| SCHEMBL3927808 | 0.75 | NPC1 (0.36) | CCNE1CDK2CCNE2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060247263-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2006-11-02 | — | — | US | claimed |
| US-20060247263-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247263-A1 | Substituted heterocyclic compounds and methods of use | MAPT, IAPP, MYLK2 | CCNE1 3302/4885CDK2 517/4885CCNE2 3333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.