Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCPS | Q96C86 | 14/20 | 0.59 |
| ▸ | DHFR | P00374 | 5/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.49 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.49 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.49 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.49 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4005326 | 0.96 | DCPS (0.58) | DCPSDHFRKCNH2CSNK1A1CSNK1D | |
| SCHEMBL4003593 | 0.94 | DCPS (0.60) | DCPSDHFRKCNH2MCHR1CYP2D6 | |
| SCHEMBL5219977 | 0.93 | DCPS (0.61) | DCPSDHFRKCNH2MCHR1CYP2D6 | |
| SCHEMBL1154212 | 0.86 | DCPS (0.77) | DCPSDHFRMCHR1CYP2D6 | |
| SCHEMBL1154891 | 0.85 | DCPS (0.79) | DCPSDHFRMCHR1CYP2D6 | |
| SCHEMBL1155035 | 0.82 | DCPS (0.79) | DCPSDHFRMCHR1CYP2D6 | |
| SCHEMBL1154903 | 0.79 | DCPS (0.83) | DCPSDHFRCYP2D6 | |
| SCHEMBL15284417 | 0.78 | CSNK1A1 (0.74) | DCPSDHFRKCNH2CSNK1A1CSNK1D | |
| SCHEMBL2165928 | 0.78 | DCPS (0.71) | DCPSDHFRCYP2D6 | |
| SCHEMBL15283746 | 0.77 | DCPS (0.57) | DCPSDHFRKCNH2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765810-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Decode Chemistry, Inc. (US) | 2007-03-28 | — | — | EP | claimed |
| WO-2005123724-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | DECODE CHEMISTRY, INC. (US) | 2005-12-29 | — | — | WO | claimed |
| EP-2069316-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Families of Spinal Muscular Atrophy (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008016973-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | FAMILIES OF SPINAL MUSCULAR ATROPHY (US) | 2008-02-07 | — | — | WO | disclosed |
| EP-1765810-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Decode Chemistry, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123724-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | DECODE CHEMISTRY, INC. (US) | 2005-12-29 | — | — | WO | disclosed |