Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.62 |
| ▸ | JAK3 | P52333 | 14/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.58 |
| ▸ | MUSK | O15146 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | STAT5B | P51692 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4004655 | 1.00 | JAK2 (0.62) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL4001803 | 0.92 | JAK2 (0.62) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL4001797 | 0.92 | JAK2 (0.62) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL4007173 | 0.90 | JAK2 (0.77) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL4007169 | 0.90 | JAK2 (0.77) | JAK2JAK3NTRK1CDK2MUSK | |
| SCHEMBL4015443 | 0.78 | JAK2 (0.81) | JAK2JAK3NTRK1CDK2RET | |
| SCHEMBL4015453 | 0.78 | JAK2 (0.81) | JAK2JAK3NTRK1CDK2RET | |
| SCHEMBL4007328 | 0.78 | JAK2 (0.76) | JAK2JAK3NTRK1RETFLT3 | |
| SCHEMBL4438437 | 0.78 | JAK2 (0.76) | JAK2JAK3NTRK1RETFLT3 | |
| SCHEMBL14041525 | 0.77 | JAK2 (1.00) | JAK2JAK3NTRK1CDK2MUSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007753-A2 | 4- (3-AMINOPYRAZOLE) -PYRIMIDINE DERIVATIVEE AND THEIR USE AS TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |