Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.77 |
| ▸ | JAK3 | P52333 | 12/20 | 0.77 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.57 |
| ▸ | AURKA | O14965 | 4/20 | 0.56 |
| ▸ | RET | P07949 | 3/20 | 0.56 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | FER | P16591 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | STAT5A | P42229 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4007169 | 1.00 | JAK2 (0.77) | JAK2JAK3NTRK1AURKARET | |
| SCHEMBL4001803 | 0.90 | JAK2 (0.62) | JAK2JAK3NTRK1RETFLT3 | |
| SCHEMBL4004655 | 0.90 | JAK2 (0.62) | JAK2JAK3NTRK1RETFLT3 | |
| SCHEMBL4004658 | 0.90 | JAK2 (0.62) | JAK2JAK3NTRK1RETFLT3 | |
| SCHEMBL4001797 | 0.90 | JAK2 (0.62) | JAK2JAK3NTRK1RETFLT3 | |
| SCHEMBL4438437 | 0.88 | JAK2 (0.76) | JAK2JAK3NTRK1AURKARET | |
| SCHEMBL4007328 | 0.88 | JAK2 (0.76) | JAK2JAK3NTRK1AURKARET | |
| SCHEMBL4006048 | 0.87 | JAK2 (1.00) | JAK2JAK3NTRK1AURKARET | |
| SCHEMBL4006062 | 0.87 | JAK2 (1.00) | JAK2JAK3NTRK1AURKARET | |
| SCHEMBL4001049 | 0.87 | JAK2 (0.64) | JAK2JAK3NTRK1AURKARET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007753-A2 | 4- (3-AMINOPYRAZOLE) -PYRIMIDINE DERIVATIVEE AND THEIR USE AS TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |