Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3557468 | 0.84 | HTR1A (0.79) | HTR1A | |
| SCHEMBL4007691 | 0.83 | HTR1A (0.57) | HTR1AUSP2LMNAPOLBTSHR | |
| SCHEMBL4007694 | 0.83 | HTR1A (0.57) | HTR1AUSP2LMNAPOLBTSHR | |
| Hydrochloric Acid SCHEMBL4007849 | 0.82 | HTR1A (0.56) | HTR1AUSP2LMNAPOLBTSHR | |
| Hydrochloric Acid SCHEMBL4004739 | 0.82 | HTR1A (0.56) | HTR1AUSP2LMNAPOLBTSHR | |
| Hydrochloric Acid SCHEMBL4004733 | 0.82 | HTR1A (0.56) | HTR1AUSP2LMNAPOLBTSHR | |
| Hydrochloric Acid SCHEMBL4007850 | 0.82 | HTR1A (0.56) | HTR1AUSP2LMNAPOLBTSHR | |
| SCHEMBL5214065 | 0.78 | HTR1A (0.54) | HTR1AUSP2LMNAPOLBTSHR | |
| SCHEMBL24336747 | 0.77 | PIM1 (0.58) | HTR1AUSP2LMNAPOLBTSHR | |
| SCHEMBL3560019 | 0.77 | HTR1A (0.77) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080675-A1 | QUINOLINE DERIVATIVES WITH AFFINITY FOR THE 5-HT2B RECEPTOR | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080675-A1 | QUINOLINE DERIVATIVES WITH AFFINITY FOR THE 5-HT2B RECEPTOR | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |