Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | S100A4 | P26447 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 10/20 | 0.49 |
| ▸ | CA1 | P00915 | 10/20 | 0.49 |
| ▸ | CA2 | P00918 | 10/20 | 0.49 |
| ▸ | CA4 | P22748 | 10/20 | 0.49 |
| ▸ | CA7 | P43166 | 10/20 | 0.49 |
| ▸ | CA9 | Q16790 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5951026 | 1.00 | KMT2A (0.60) | KMT2AMEN1S100A4TRPV1TRPM8 | |
| SCHEMBL5950661 | 0.85 | NOTUM (0.46) | KMT2AMEN1S100A4POLB | |
| SCHEMBL4003634 | 0.85 | NOTUM (0.46) | KMT2AMEN1S100A4POLB | |
| SCHEMBL4001935 | 0.77 | HSD11B1 (0.41) | KMT2APOLBHSD11B1 | |
| SCHEMBL4143457 | 0.77 | HSD11B1 (0.41) | KMT2APOLBHSD11B1 | |
| SCHEMBL13005148 | 0.77 | TRPV1 (0.57) | KMT2AMEN1S100A4TRPV1TRPM8 | |
| SCHEMBL5575433 | 0.76 | TRPV1 (0.66) | KMT2AMEN1S100A4TRPV1TRPM8 | |
| SCHEMBL4152378 | 0.75 | KMT2A (0.56) | KMT2AMEN1S100A4TRPV1HSD11B1 | |
| SCHEMBL4448283 | 0.75 | KMT2A (0.56) | KMT2AMEN1S100A4TRPV1HSD11B1 | |
| SCHEMBL4002921 | 0.75 | EPHX2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| US-20060122197-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2006-06-08 | — | — | US | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |
| US-20060122197-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122197-A1 | Amido compounds and their use as pharmaceuticals | HSD11B1, CYP11B1, HSD11B2 | KMT2A 3418/4885MEN1 379/4885S100A4 4828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.