Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4005445 | 1.00 | HSD11B1 (0.65) | HSD11B1RAB9AUSP2MAPK1EPHX2 | |
| SCHEMBL4138538 | 0.88 | HSD11B1 (0.70) | HSD11B1RAB9AMAPK1EPHX2ALDH1A1 | |
| SCHEMBL612467 | 0.88 | HSD11B1 (0.75) | HSD11B1RAB9AUSP2MAPK1EPHX2 | |
| SCHEMBL4010554 | 0.88 | HSD11B1 (0.75) | HSD11B1RAB9AUSP2MAPK1EPHX2 | |
| SCHEMBL27707777 | 0.86 | HSD11B1 (0.48) | HSD11B1RAB9AUSP2MAPK1EPHX2 | |
| SCHEMBL4009206 | 0.85 | HSD11B1 (0.68) | HSD11B1ALDH1A1 | |
| SCHEMBL4009203 | 0.85 | HSD11B1 (0.68) | HSD11B1ALDH1A1 | |
| SCHEMBL4142798 | 0.84 | HSD11B1 (0.90) | HSD11B1RAB9AEPHX2ALDH1A1TP53 | |
| SCHEMBL4005619 | 0.83 | HSD11B1 (0.68) | HSD11B1RAB9AEPHX2 | |
| SCHEMBL4005615 | 0.83 | HSD11B1 (0.68) | HSD11B1RAB9AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |