Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.61 |
| ▸ | STK3 | Q13188 | 3/20 | 0.59 |
| ▸ | CDC7 | O00311 | 1/20 | 0.59 |
| ▸ | ROS1 | P08922 | 1/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.59 |
| ▸ | MARK3 | P27448 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | CDK8 | P49336 | 1/20 | 0.59 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.59 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.59 |
| ▸ | MELK | Q14680 | 1/20 | 0.59 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.59 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.59 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.59 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.59 |
| ▸ | AKT1 | P31749 | 7/20 | 0.54 |
| ▸ | STK4 | Q13043 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.50 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3955185 | 0.81 | LRRK2 (0.63) | LRRK2STK3CDC7ROS1KIT | |
| SCHEMBL3536069 | 0.79 | AKT1 (0.69) | LRRK2STK3CDC7ROS1KIT | |
| SCHEMBL4298450 | 0.79 | AKT1 (0.64) | LRRK2STK3CDC7ROS1KIT | |
| SCHEMBL3536255 | 0.76 | LRRK2 (0.58) | LRRK2STK3CDC7ROS1KIT | |
| SCHEMBL15401270 | 0.76 | LRRK2 (1.00) | LRRK2STK3CDC7ROS1KIT | |
| SCHEMBL3535567 | 0.76 | CHUK (0.67) | LRRK2STK3CDC7ROS1KIT | |
| SCHEMBL3954467 | 0.76 | LRRK2 (0.58) | LRRK2STK3CDC7ROS1KIT | |
| SCHEMBL2253309 | 0.75 | AKT1 (0.57) | KITAKT1AKT2AKT3 | |
| SCHEMBL28021225 | 0.75 | AKT1 (0.52) | LRRK2KITAKT1AKT2AKT3 | |
| SCHEMBL3535044 | 0.75 | LRRK2 (1.00) | LRRK2STK3CDC7ROS1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |