Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.49 |
| ▸ | GUCY1A1 | Q02108 | 12/20 | 0.45 |
| ▸ | GUCY1B1 | Q02153 | 12/20 | 0.45 |
| ▸ | XDH | P47989 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4004694 | 0.92 | KEAP1 (0.46) | KEAP1NFE2L2GUCY1A1GUCY1B1 | |
| SCHEMBL4001015 | 0.91 | KEAP1 (0.47) | KEAP1NFE2L2GUCY1A1GUCY1B1XDH | |
| SCHEMBL3998252 | 0.90 | KEAP1 (0.48) | KEAP1NFE2L2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3996801 | 0.85 | KEAP1 (0.46) | KEAP1NFE2L2GUCY1A1GUCY1B1 | |
| SCHEMBL4005104 | 0.85 | KEAP1 (0.46) | KEAP1NFE2L2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3994730 | 0.85 | KEAP1 (0.45) | KEAP1NFE2L2GUCY1A1GUCY1B1 | |
| SCHEMBL3998240 | 0.84 | KEAP1 (0.46) | KEAP1NFE2L2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3998373 | 0.84 | KEAP1 (0.47) | KEAP1NFE2L2GUCY1A1GUCY1B1 | |
| SCHEMBL3996947 | 0.84 | KEAP1 (0.48) | KEAP1NFE2L2GUCY1A1GUCY1B1KDM4E | |
| SCHEMBL3996991 | 0.84 | KEAP1 (0.47) | KEAP1NFE2L2GUCY1A1GUCY1B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| WO-2015095515-A1 | SGC ACTIVATORS FOR THE TREATMENT OF GLAUCOMA | NOVARTIS AG (CH) | 2015-06-25 | — | — | WO | disclosed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |