Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.58 |
| ▸ | RAF1 | P04049 | 7/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.56 |
| ▸ | BRAF | P15056 | 9/20 | 0.53 |
| ▸ | ABL1 | P00519 | 4/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.52 |
| ▸ | RET | P07949 | 3/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.52 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29396481 | 1.00 | KDR (0.58) | KDRRAF1EPHX2BRAFABL1 | |
| Water SCHEMBL2991434 | 0.99 | KDR (0.57) | KDRRAF1EPHX2BRAFABL1 | |
| SCHEMBL14629918 | 0.91 | KDR (0.49) | KDRRAF1EPHX2BRAFABL1 | |
| SCHEMBL29376840 | 0.91 | KDR (0.49) | KDRRAF1EPHX2BRAFABL1 | |
| SCHEMBL30078261 | 0.90 | KDR (0.61) | KDRRAF1EPHX2BRAFABL1 | |
| SCHEMBL6387865 | 0.90 | KDR (0.61) | KDRRAF1EPHX2BRAFABL1 | |
| SCHEMBL6427214 | 0.88 | KDR (0.59) | KDRRAF1EPHX2BRAFABL1 | |
| SCHEMBL940461 | 0.88 | KDR (0.62) | KDRRAF1EPHX2BRAFABL1 | |
| SCHEMBL29834753 | 0.86 | ABL1 (0.46) | KDRRAF1EPHX2BRAFABL1 | |
| SCHEMBL28407666 | 0.86 | GRM5 (0.44) | KDRRAF1EPHX2BRAFABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 285 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315710-B | Method for preparing or purifying regorafenib | 江苏豪森药业集团有限公司 | 2024-04-26 | — | — | CN | claimed |
| CN-114315710-A | Method for preparing or purifying regorafenib | 江苏豪森药业集团有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-112679424-A | Synthesis method of regorafenib | 苏州特瑞药业有限公司 | 2021-04-20 | — | — | CN | claimed |
| CN-105777625-B | Method for preparing 4- (4-amino-3-fluorophenoxy) -N-methylpyridine-2-formamide | 浙江海正药业股份有限公司 | 2020-05-22 | — | — | CN | claimed |
| US-20190300484-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF REGORAFENIB | NATCO PHARMA LTD (IN) | 2019-10-03 | — | — | US | claimed |
| CN-110183377-A | A kind of synthetic method of anticancer drug Rui Gefeini | 浙江工业大学上虞研究院有限公司 | 2019-08-30 | — | — | CN | claimed |
| US-10144710-B2 | Process for the preparation of 4-[-({[4-choloro-3(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide and its polymorphs thereof | MSN LABORATORIES PRIVATE LIMITED (IN) | 2018-12-04 | — | — | US | claimed |
| US-10081599-B2 | Preparation method of 4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-formamide | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2018-09-25 | — | — | US | claimed |
| US-20170334856-A1 | PREPARATION METHOD OF 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPYRIDINE-2-FORMAMIDE | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2017-11-23 | — | — | US | claimed |
| EP-3243508-A1 | COATED PHARMACEUTICAL COMPOSITION CONTAINING REGORAFENIB | Bayer Healthcare LLC (US) | 2017-11-15 | — | — | EP | claimed |
| WO-2015049698-A2 | PROCESS FOR REGORAFENIB | HETERO RESEARCH FOUNDATION (IN) | 2015-04-09 | — | — | WO | claimed |
| WO-2015011659-A1 | CRYSTALLINE POLYMORPHIC FORMS OF REGORAFENIB AND PROCESSES FOR THE PREPARATION OF POLYMORPH I OF REGORAFENIB | DR. REDDYS LABORATORIES LIMITED (IN) | 2015-01-29 | — | — | WO | claimed |
| US-20140221661-A1 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-ETHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-08-07 | — | — | US | claimed |
| US-20140065212-A1 | COATED PHARMACEUTICAL COMPOSITION CONTAINING REGORAFENIB | BAYER HEALTHCARE LLC (US) | 2014-03-06 | — | — | US | claimed |
| US-20130116442-A1 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-09 | — | — | US | claimed |
| EP-2558448-A1 | PROCESS FOR THE PREPARATION OF 4- {4-[({[4 -CHLORO-3 -(TRIFLUOROMETHYL)-PHENYL]AMINO}CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | Bayer HealthCare LLC (US) | 2013-02-20 | — | — | EP | claimed |
| WO-2011128261-A1 | PROCESS FOR THE PREPARATION OF 4- {4-[({[4 -CHLORO-3 -(TRIFLUOROMETHYL)-PHENYL]AMINO}CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-10-20 | — | — | WO | claimed |
| US-20100113533-A1 | Polymorph II of 4-[4-(Amino)-3- Fluorophenoxy]-N-Methylpyridine-2-Carboxamide | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-05-06 | — | — | US | claimed |
| EP-2089363-A1 | POLYMORPH II OF 4-[4-({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]N-METHYLPYRIDINE-2-CARBOXAMIDE | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-08-19 | — | — | EP | claimed |
| WO-2008058644-A1 | POLYMORPH II OF 4-[4-({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-05-22 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10144710-B2 | Process for the preparation of 4-[-({[4-choloro-3(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide and its polymorphs thereof | CYP4X1, CYP4B1, CYP4F12 | KDR 4062/4885RAF1 4071/4885EPHX2 624/4885 |
| US-20190300484-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF REGORAFENIB | KRAS, NRAS, HRAS | KDR 91/4885RAF1 15/4885EPHX2 1487/4885 |
| US-20170334856-A1 | PREPARATION METHOD OF 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPYRIDINE-2-FORMAMIDE | MTAP, KCNH2, KCNN4 | KDR 2483/4885RAF1 2868/4885EPHX2 1969/4885 |
| US-20140221661-A1 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-ETHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | ACMSD, DNPEP, CPS1 | KDR 2111/4885RAF1 2344/4885EPHX2 1455/4885 |
| US-20100113533-A1 | Polymorph II of 4-[4-(Amino)-3- Fluorophenoxy]-N-Methylpyridine-2-Carboxamide | CYP3A4, CYP1A2, CYP3A5 | KDR 3733/4885RAF1 3449/4885EPHX2 1661/4885 |
| US-20140065212-A1 | COATED PHARMACEUTICAL COMPOSITION CONTAINING REGORAFENIB | KRAS, NRAS, BRAF | KDR 21/4885RAF1 27/4885EPHX2 2473/4885 |
| US-20130116442-A1 | PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE | ACMSD, DNPEP, CPS1 | KDR 2454/4885RAF1 2574/4885EPHX2 2535/4885 |
| US-10081599-B2 | Preparation method of 4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-formamide | MTAP, KCNH2, KCNN4 | KDR 2483/4885RAF1 2868/4885EPHX2 1969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.