Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | RXRB | P28702 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263895 | 0.83 | MGAM (0.51) | MGAMKMT2AMEN1MAPTKDM4E | |
| SCHEMBL264755 | 0.80 | ATM (0.35) | KMT2AMEN1MAPTSCN10ANFKB1 | |
| SCHEMBL1285055 | 0.73 | MGAM (0.50) | MGAMKMT2AMEN1MAPTCNR2 | |
| SCHEMBL12458277 | 0.73 | MGAM (0.53) | MGAMKMT2AMEN1MAPTCNR2 | |
| SCHEMBL15828574 | 0.71 | ALDH1A1 (0.34) | KMT2AMEN1MAPTSCN10ANFKB1 | |
| SCHEMBL269263 | 0.70 | MEN1 (0.44) | MGAMKMT2AMEN1MAPTTRPV1 | |
| SCHEMBL1285735 | 0.69 | BACE1 (0.56) | MGAMCNR2KDM4ESCN10ASCN9A | |
| SCHEMBL283861 | 0.68 | MEN1 (0.42) | KMT2AMEN1SCN10ASCN9A | |
| SCHEMBL25497861 | 0.67 | MEN1 (0.47) | KMT2AMEN1MAPTTRPV1SCN10A | |
| SCHEMBL3726302 | 0.67 | PTPN1 (0.45) | MGAMKMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069302-A1 | SUBSTITUTED PYRIDYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | Pfizer Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008032204-A1 | SUBSTITUTED PYRIDYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER JAPAN INC. (JP) | 2008-03-20 | — | — | WO | disclosed |