Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.55 |
| ▸ | JAK3 | P52333 | 9/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.47 |
| ▸ | PRKACA | P17612 | 5/20 | 0.44 |
| ▸ | GSK3A | P49840 | 5/20 | 0.44 |
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.44 |
| ▸ | CLK2 | P49760 | 4/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15032780 | 0.83 | KIT (0.44) | JAK2JAK3DYRK1ANTRK1KIT | |
| SCHEMBL15032863 | 0.81 | JAK3 (0.68) | JAK2JAK3ROCK2LIMK1LRRK2 | |
| SCHEMBL20195296 | 0.80 | LIMK1 (0.69) | JAK2JAK3ROCK2LIMK1LRRK2 | |
| SCHEMBL15010414 | 0.80 | JAK2 (0.55) | JAK2JAK3ROCK2LIMK1LRRK2 | |
| SCHEMBL15032846 | 0.77 | PIK3CD (0.46) | JAK2JAK3 | |
| SCHEMBL20184432 | 0.76 | JAK3 (0.68) | JAK2JAK3ROCK2LIMK1 | |
| SCHEMBL4006360 | 0.75 | BRAF (0.60) | ROCK2LIMK1LRRK2PRKACAGSK3B | |
| SCHEMBL20184454 | 0.74 | JAK3 (0.70) | JAK2JAK3ROCK2LIMK1 | |
| SCHEMBL4790325 | 0.73 | LRRK2 (0.61) | JAK2JAK3ROCK2LIMK1LRRK2 | |
| SCHEMBL15032654 | 0.71 | JAK3 (1.00) | JAK2JAK3ROCK2LIMK1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |