Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.68 |
| ▸ | JAK2 | O60674 | 8/20 | 0.68 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.63 |
| ▸ | PRKACA | P17612 | 6/20 | 0.60 |
| ▸ | GSK3B | P49841 | 6/20 | 0.60 |
| ▸ | GSK3A | P49840 | 5/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.60 |
| ▸ | CLK2 | P49760 | 4/20 | 0.60 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.60 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.60 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.60 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.60 |
| ▸ | PAK4 | O96013 | 3/20 | 0.60 |
| ▸ | CDK8 | P49336 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15032653 | 0.83 | JAK3 (0.57) | JAK3JAK2LRRK2PRKACAGSK3B | |
| SCHEMBL7021288 | 0.83 | LRRK2 (0.63) | JAK3JAK2LRRK2PRKACAGSK3B | |
| SCHEMBL15032857 | 0.82 | JAK3 (0.66) | JAK3JAK2LRRK2PRKACAGSK3B | |
| SCHEMBL15010414 | 0.81 | JAK2 (0.55) | JAK3JAK2LRRK2PRKACAGSK3B | |
| SCHEMBL4007170 | 0.81 | JAK2 (0.55) | JAK3JAK2LRRK2PRKACAGSK3B | |
| SCHEMBL20195296 | 0.81 | LIMK1 (0.69) | JAK3JAK2LRRK2PRKACAGSK3B | |
| SCHEMBL3226104 | 0.81 | LRRK2 (0.61) | JAK3JAK2LRRK2PRKACAGSK3B | |
| SCHEMBL29378308 | 0.81 | LRRK2 (0.61) | JAK3JAK2LRRK2PRKACAGSK3B | |
| SCHEMBL15032654 | 0.81 | JAK3 (1.00) | JAK3JAK2LRRK2PRKACAGSK3B | |
| SCHEMBL16245402 | 0.80 | JAK3 (0.75) | JAK3JAK2LRRK2PRKACAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |
| US-8993756-B2 | Pyrrolopyrimidines as janus kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-03-31 | — | — | US | claimed |
| US-20140349998-A1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIITORS | MERCK SHARP & DOHME CORP. (US) | 2014-11-27 | — | — | US | claimed |
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | disclosed |
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | disclosed |
| US-8993756-B2 | Pyrrolopyrimidines as janus kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-03-31 | — | — | US | disclosed |
| US-8993756-B2 | Pyrrolopyrimidines as janus kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-03-31 | — | — | US | disclosed |
| US-8993756-B2 | Pyrrolopyrimidines as janus kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140349998-A1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIITORS | MERCK SHARP & DOHME CORP. (US) | 2014-11-27 | — | — | US | disclosed |
| US-20140349998-A1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIITORS | MERCK SHARP & DOHME CORP. (US) | 2014-11-27 | — | — | US | disclosed |
| US-20140349998-A1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIITORS | MERCK SHARP & DOHME CORP. (US) | 2014-11-27 | — | — | US | disclosed |
| WO-2013085802-A1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140349998-A1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIITORS | JAK3, JAK1, JAK2 | JAK3 1/4885JAK2 3/4885LRRK2 2468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.