Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 11/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 11/20 | 0.62 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNG | P07510 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRND | Q07001 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4007166 | 0.90 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL7687914 | 0.85 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL4012078 | 0.85 | CHRNB2 (0.70) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL7683985 | 0.81 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL13767889 | 0.80 | CHRNB2 (0.74) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL4009056 | 0.80 | CHRNB4 (0.54) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL7684006 | 0.79 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL4012217 | 0.79 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL4005481 | 0.78 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL5389396 | 0.78 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081246-A2 | BICYCLIC DIAMINES AS NICOTINIC RECEPTOR AGONISTS | PFIZER INC. (US) | 2009-07-02 | — | — | WO | claimed |