Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 19/20 | 0.69 |
| ▸ | PRKDC | P78527 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4010962 | 0.90 | ATR (0.68) | ATRPRKDCATMEGFR | |
| SCHEMBL3057768 | 0.82 | ATR (1.00) | ATRPRKDCATM | |
| SCHEMBL4009915 | 0.81 | ATR (0.77) | ATRPRKDCATMEGFR | |
| SCHEMBL4564500 | 0.81 | ATR (0.64) | ATRPRKDCATMEGFR | |
| SCHEMBL2387411 | 0.80 | ATR (0.57) | ATRPRKDCATM | |
| SCHEMBL4006264 | 0.79 | ATR (0.69) | ATRPRKDCATMEGFR | |
| SCHEMBL4009691 | 0.79 | ATR (0.72) | ATRPRKDCATMEGFR | |
| SCHEMBL4297778 | 0.79 | ATR (0.58) | ATRPRKDCATMEGFR | |
| SCHEMBL2484717 | 0.79 | ATR (1.00) | ATRPRKDCATMEGFR | |
| SCHEMBL4009550 | 0.78 | ATR (0.72) | ATRPRKDCATMEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |