Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 13/20 | 0.58 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | PRKDC | P78527 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4006573 | 0.93 | ATR (0.59) | ATREGFRPRKDCATM | |
| SCHEMBL3927916 | 0.83 | ATR (0.48) | ATRMAP3K11ADORA2A | |
| SCHEMBL4158549 | 0.82 | MAP3K11 (0.50) | MAP3K11ADORA2AEGFRKITJAK2 | |
| SCHEMBL4009811 | 0.82 | MCHR1 (0.49) | ATRMAP3K11ADORA2A | |
| SCHEMBL4012928 | 0.82 | ATR (0.54) | ATRMAP3K11ADORA2A | |
| SCHEMBL4452119 | 0.81 | ATR (0.61) | ATRPRKDCATM | |
| SCHEMBL4009857 | 0.81 | MCHR1 (0.51) | ATRMAP3K11ADORA2A | |
| SCHEMBL13956736 | 0.80 | EGFR (0.53) | ATREGFRPRKDCATM | |
| SCHEMBL4004985 | 0.80 | ATR (0.47) | ATRMAP3K11ADORA2APRKDCATM | |
| SCHEMBL4008321 | 0.79 | ATR (0.55) | ATRMAP3K11ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |