Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.61 |
| ▸ | ABHD6 | Q9BV23 | 6/20 | 0.59 |
| ▸ | ACACB | O00763 | 3/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
| ▸ | PTAFR | P25105 | 2/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 3/20 | 0.45 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12269322 | 0.88 | NOTUM (0.61) | NOTUMABHD6CARM1PTAFRBAZ2B | |
| SCHEMBL1550147 | 0.86 | ABHD6 (0.60) | NOTUMABHD6ACACBAKR1C3CARM1 | |
| SCHEMBL16269157 | 0.84 | ABHD6 (0.55) | ABHD6ACACBAKR1C3CARM1PRMT6 | |
| SCHEMBL10210758 | 0.83 | NOTUM (0.63) | NOTUMABHD6PTAFRBAZ2BTRAP1 | |
| SCHEMBL6712189 | 0.83 | NOTUM (0.63) | NOTUMABHD6AKR1C3PTAFRBAZ2B | |
| SCHEMBL15935190 | 0.82 | NOTUM (0.58) | NOTUMABHD6ACACBPTAFRBAZ2B | |
| SCHEMBL10356953 | 0.81 | NOTUM (0.61) | NOTUMABHD6AKR1C3PTAFRBAZ2B | |
| SCHEMBL4512420 | 0.81 | NOTUM (0.61) | NOTUMACACBAKR1C3PTAFRTRAP1 | |
| SCHEMBL28739037 | 0.81 | ABHD6 (0.55) | ABHD6AKR1C3TRAP1LMNA | |
| SCHEMBL22461027 | 0.81 | ABHD6 (0.55) | ABHD6AKR1C3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007747-A2 | HYDANTOIN DERIVATIVES USED AS MMP12 INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |