Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.69 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.63 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | IKBKB | O14920 | 2/20 | 0.51 |
| ▸ | CHUK | O15111 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 9/20 | 0.50 |
| ▸ | MELK | Q14680 | 1/20 | 0.50 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.49 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.49 |
| ▸ | PAK4 | O96013 | 4/20 | 0.49 |
| ▸ | CSF1R | P07333 | 4/20 | 0.49 |
| ▸ | RET | P07949 | 4/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.49 |
| ▸ | PRKACA | P17612 | 4/20 | 0.49 |
| ▸ | FLT1 | P17948 | 4/20 | 0.49 |
| ▸ | LTK | P29376 | 4/20 | 0.49 |
| ▸ | GRK5 | P34947 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4006751 | 0.82 | JAK2 (1.00) | JAK2IKBKBCHUKJAK3MELK | |
| SCHEMBL30406768 | 0.79 | IKBKB (0.55) | JAK2NUDT1AXLIKBKBCHUK | |
| SCHEMBL415754 | 0.78 | NUDT1 (1.00) | JAK2NUDT1IKBKBCHUKJAK3 | |
| SCHEMBL13885161 | 0.75 | JAK2 (0.69) | JAK2AXLIKBKBCHUKJAK3 | |
| SCHEMBL17489713 | 0.75 | CDK5 (0.47) | NUDT1AXLJAK3KDRLRRK2 | |
| SCHEMBL15661937 | 0.74 | JAK2 (0.67) | JAK2NUDT1AXLIKBKBCHUK | |
| SCHEMBL4582660 | 0.74 | JAK2 (0.67) | JAK2AXLIKBKBCHUKJAK3 | |
| SCHEMBL4582666 | 0.74 | JAK2 (0.67) | JAK2AXLIKBKBCHUKJAK3 | |
| SCHEMBL13878218 | 0.73 | JAK2 (0.67) | JAK2IKBKBCHUKJAK3MELK | |
| SCHEMBL13765436 | 0.73 | JAK2 (0.72) | JAK2IKBKBCHUKJAK3MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080682-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |