Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13959224 | 0.81 | ADORA2A (0.43) | KMT2AADORA1ADORA2A | |
| SCHEMBL29814700 | 0.74 | KDM4E (0.46) | KDM4EKMT2AADORA1ADORA2APDK2 | |
| SCHEMBL23089134 | 0.74 | KDM4E (0.46) | KDM4EKMT2AADORA1ADORA2APDK2 | |
| SCHEMBL23132920 | 0.72 | ADORA1 (0.46) | KDM4EKMT2AADORA1ADORA2APDK2 | |
| SCHEMBL24859522 | 0.72 | KDM4E (0.44) | KDM4EKMT2AADORA1ADORA2APDK2 | |
| SCHEMBL23103525 | 0.72 | KDM4E (0.44) | KDM4EKMT2AADORA1ADORA2APDK2 | |
| SCHEMBL19249730 | 0.69 | CCR1 (0.41) | KMT2AMEN1 | |
| SCHEMBL23106887 | 0.69 | ADORA1 (0.55) | KDM4EKMT2AADORA1ADORA2APDK2 | |
| SCHEMBL8324036 | 0.68 | IDO1 (0.38) | KDM4EKMT2AADORA1ADORA2AMEN1 | |
| SCHEMBL9695650 | 0.67 | HTT (0.51) | KDM4EKMT2AADORA1ADORA2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009005672-A1 | ANTIDIABETIC AZAINDOLES AND DIAZAINDOLES | MERCK & CO., INC. (US) | 2009-01-08 | — | — | WO | disclosed |
| WO-2009005672-A1 | ANTIDIABETIC AZAINDOLES AND DIAZAINDOLES | MERCK & CO., INC. (US) | 2009-01-08 | — | — | WO | disclosed |