Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | AHR | P35869 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322361 | 0.73 | ADORA2A (0.42) | KDM4EKMT2AMAPTAHRALDH1A1 | |
| SCHEMBL8324129 | 0.73 | ADORA1 (0.54) | KDM4EKMT2AMAPTAHRADORA2A | |
| SCHEMBL22057625 | 0.69 | PARP1 (0.51) | KDM4EKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL4009713 | 0.68 | KDM4E (0.45) | KDM4EKMT2AALDH1A1MEN1ADORA2A | |
| SCHEMBL18103887 | 0.66 | HTR2A (0.43) | IDO1KDM4E | |
| SCHEMBL18103896 | 0.65 | TAAR1 (0.43) | KMT2A | |
| SCHEMBL855363 | 0.63 | KDM4E (0.50) | KDM4EMAPTAHRALDH1A1ADORA2A | |
| SCHEMBL13959224 | 0.62 | ADORA2A (0.43) | KMT2AMAPTADORA2AADORA1 | |
| SCHEMBL8326471 | 0.62 | KDM4E (0.33) | KDM4EMAPTALDH1A1GAAHPGD | |
| SCHEMBL23089134 | 0.62 | KDM4E (0.46) | KDM4EKMT2AALDH1A1MEN1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509974-B1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | ASTRA AB (SE) | 1999-01-13 | — | — | EP | disclosed |
| US-5439917-A | Phenyl-pyrrolo(2,3-b)pyridine antisecretory agent of gastric acid; adenosine triphosphatase enzyme inhibitor | AKTIEBOLAGET ASTRA (SE) | 1995-08-08 | — | — | US | disclosed |
| EP-0580616-A1 | NEW ACTIVE COMPOUNDS | Astra Aktiebolag (SE) | 1994-02-02 | — | — | EP | disclosed |
| EP-0509974-A1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | Astra Aktiebolag (SE) | 1992-10-21 | — | — | EP | disclosed |
| WO-1992017477-A1 | NEW ACTIVE COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1992-10-15 | — | — | WO | disclosed |