Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009764 | 1.00 | HSD11B1 (0.62) | HSD11B1TSHRLMNAMAPK1NPSR1 | |
| Hydrochloric Acid SCHEMBL3999535 | 0.99 | HSD11B1 (0.61) | HSD11B1TSHRLMNAMAPK1NPSR1 | |
| Hydrochloric Acid SCHEMBL3999537 | 0.99 | HSD11B1 (0.61) | HSD11B1TSHRLMNAMAPK1NPSR1 | |
| SCHEMBL1299167 | 0.83 | TSHR (0.68) | HSD11B1TSHRLMNAMAPK1ALDH1A1 | |
| SCHEMBL27688390 | 0.82 | TSHR (0.47) | HSD11B1TSHRLMNAMAPK1NPSR1 | |
| SCHEMBL27707767 | 0.82 | TSHR (0.47) | HSD11B1TSHRLMNAMAPK1NPSR1 | |
| SCHEMBL5243753 | 0.82 | HSD11B1 (0.72) | HSD11B1TSHRMAPTKMT2ATP53 | |
| SCHEMBL4010554 | 0.80 | HSD11B1 (0.75) | HSD11B1TSHRLMNAMAPK1NPSR1 | |
| SCHEMBL612467 | 0.80 | HSD11B1 (0.75) | HSD11B1TSHRLMNAMAPK1NPSR1 | |
| SCHEMBL4739901 | 0.79 | HSD11B1 (0.61) | HSD11B1TSHRLMNAMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |