Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.57 |
| ▸ | JAK2 | O60674 | 14/20 | 0.54 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009997 | 1.00 | JAK3 (0.57) | JAK3JAK2PIK3C3IGF1RAURKA | |
| SCHEMBL4007185 | 0.89 | JAK2 (0.54) | JAK3JAK2PIK3C3IGF1RAURKA | |
| SCHEMBL4007177 | 0.89 | JAK2 (0.54) | JAK3JAK2PIK3C3IGF1RAURKA | |
| SCHEMBL220721 | 0.84 | JAK3 (0.79) | JAK3JAK2IGF1RAURKAAURKB | |
| SCHEMBL13942598 | 0.75 | JAK3 (0.72) | JAK3JAK2 | |
| SCHEMBL218817 | 0.73 | JAK2 (0.73) | JAK3JAK2 | |
| SCHEMBL4982579 | 0.73 | JAK2 (0.80) | JAK3JAK2 | |
| SCHEMBL251027 | 0.73 | JAK2 (0.51) | JAK3JAK2IGF1R | |
| SCHEMBL220863 | 0.73 | JAK3 (1.00) | JAK3JAK2IGF1RAURKAAURKB | |
| SCHEMBL217138 | 0.72 | JAK2 (0.82) | JAK3JAK2AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007753-A2 | 4- (3-AMINOPYRAZOLE) -PYRIMIDINE DERIVATIVEE AND THEIR USE AS TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |