Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 18/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 16/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35460 | 0.83 | NR1H2 (0.61) | NR1H2NR1H3HSD17B1HSD17B2 | |
| SCHEMBL35135 | 0.81 | NR1H2 (0.64) | NR1H2NR1H3 | |
| SCHEMBL4012944 | 0.74 | NR1H2 (0.79) | NR1H2NR1H3 | |
| SCHEMBL1125162 | 0.72 | NR1H2 (0.58) | NR1H2NR1H3 | |
| SCHEMBL1125801 | 0.72 | NR1H2 (0.52) | NR1H2NR1H3 | |
| SCHEMBL4011832 | 0.70 | NR1H2 (0.64) | NR1H2NR1H3 | |
| SCHEMBL1125912 | 0.69 | NR1H2 (0.52) | NR1H2NR1H3 | |
| SCHEMBL2766777 | 0.69 | ALDH1A1 (0.48) | NR1H2NR1H3MAPT | |
| SCHEMBL1125269 | 0.68 | NR1H2 (0.53) | NR1H2NR1H3 | |
| SCHEMBL1125990 | 0.68 | NR1H2 (0.50) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |