SCHEMBL4010725

SCHEMBL4010725

CN(C)C(=O)Oc1ccc2c(c1)CCN(C)C2CCOc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.70

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ACHE P22303 3/20 0.70
SLC6A4 P31645 3/20 0.70
GAA P10253 1/20 0.48
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 1/20 0.42
KMT2A Q03164 1/20 0.41
TDP1 Q9NUW8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3862986 0.99 ACHE (0.69) ACHESLC6A4GAAKDM4EALDH1A1
SCHEMBL4012414 0.89 ACHE (0.57) ACHESLC6A4GAAALDH1A1KMT2A
SCHEMBL4006019 0.89 ACHE (0.57) ACHESLC6A4GAAALDH1A1KMT2A
Hydrochloric Acid SCHEMBL3866003 0.88 ACHE (0.56) ACHESLC6A4GAAALDH1A1KMT2A
Hydrochloric Acid SCHEMBL3866001 0.88 ACHE (0.56) ACHESLC6A4GAAALDH1A1KMT2A
SCHEMBL4012541 0.84 ACHE (0.55) ACHESLC6A4GAAALDH1A1KMT2A
SCHEMBL8522880 0.84 ACHE (0.48) ACHESLC6A4
Hydrochloric Acid SCHEMBL3870117 0.84 ACHE (0.54) ACHESLC6A4GAAALDH1A1KMT2A
SCHEMBL3863710 0.82 ACHE (1.00) ACHESLC6A4GAAKDM4EALDH1A1
SCHEMBL4006173 0.82 ACHE (1.00) ACHESLC6A4GAAKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7504393-B2 Benzylamine analogues BTG INTERNATIONAL LIMITED (GB) 2009-03-17 US claimed