Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 15/20 | 0.56 |
| ▸ | NR1H3 | Q13133 | 15/20 | 0.56 |
| ▸ | RXRA | P19793 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011231 | 0.91 | NR1H2 (0.47) | NR1H2NR1H3RXRAAXLMAPK14 | |
| SCHEMBL4015147 | 0.91 | NR1H2 (0.50) | NR1H2NR1H3RXRAAXLMAPK14 | |
| SCHEMBL4017304 | 0.90 | NR1H2 (0.46) | NR1H2NR1H3RXRAFLT1KDR | |
| SCHEMBL4011122 | 0.89 | NR1H2 (0.58) | NR1H2NR1H3RXRAAXLMAPK14 | |
| SCHEMBL4011491 | 0.88 | NR1H2 (0.64) | NR1H2NR1H3RXRACDK9AURKA | |
| SCHEMBL4011973 | 0.88 | NR1H2 (0.58) | NR1H2NR1H3RXRA | |
| SCHEMBL4013598 | 0.87 | CYP4F2 (0.43) | NR1H2NR1H3RXRACDK9CCNT1 | |
| SCHEMBL4010921 | 0.86 | NR1H2 (0.76) | NR1H2NR1H3RXRA | |
| SCHEMBL4009593 | 0.86 | NR1H2 (0.55) | NR1H2NR1H3RXRACDK9CCNT1 | |
| SCHEMBL4019328 | 0.85 | NR1H2 (0.75) | NR1H2NR1H3RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |