Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.41 |
| ▸ | CDK9 | P50750 | 6/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4011836 | 0.89 | NR1H2 (0.48) | CYP4F2CYP4A11FFAR1NR1H2NR1H3 | |
| SCHEMBL4011406 | 0.89 | CYP4F2 (0.44) | CYP4F2CYP4A11FFAR1NR1H2NR1H3 | |
| SCHEMBL4010852 | 0.87 | NR1H2 (0.56) | NR1H2NR1H3RXRACCNT1CDK9 | |
| SCHEMBL4009593 | 0.82 | NR1H2 (0.55) | NR1H2NR1H3RXRACCNT1CDK9 | |
| SCHEMBL4011231 | 0.80 | NR1H2 (0.47) | NR1H2NR1H3RXRAPTGDR2 | |
| SCHEMBL4015147 | 0.80 | NR1H2 (0.50) | NR1H2NR1H3RXRAPTGDR2 | |
| SCHEMBL4016946 | 0.80 | HTR1A (0.47) | CYP4F2CYP4A11PTGDR2 | |
| SCHEMBL4017304 | 0.79 | NR1H2 (0.46) | NR1H2NR1H3RXRAPTGDR2 | |
| SCHEMBL4018578 | 0.77 | PTGDR2 (0.41) | NR1H2NR1H3RXRAPTGDR2PDE4A | |
| SCHEMBL4012339 | 0.77 | NR1H2 (0.49) | CYP4F2CYP4A11FFAR1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |