Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27914873 | 0.86 | NAMPT (0.49) | ESR1ESR2NPC1RAB9AKMT2A | |
| SCHEMBL22981196 | 0.85 | ESR1 (0.43) | ESR1ESR2NPC1RAB9AKMT2A | |
| SCHEMBL27933360 | 0.82 | NPC1 (0.43) | ESR1ESR2NPC1RAB9AKMT2A | |
| SCHEMBL4019716 | 0.81 | ESR1 (0.41) | ESR1ESR2NPC1RAB9AKMT2A | |
| SCHEMBL16634622 | 0.80 | NAMPT (0.49) | ESR1ESR2NPC1RAB9AKMT2A | |
| SCHEMBL4015963 | 0.80 | NR1H2 (0.67) | ESR1ESR2NPC1RAB9ATMEM97 | |
| SCHEMBL19717635 | 0.79 | NPC1 (0.45) | ESR1ESR2NPC1RAB9AKMT2A | |
| SCHEMBL1648634 | 0.78 | ESR2 (0.68) | ESR1ESR2KMT2ANOTUMNR1H2 | |
| SCHEMBL30199245 | 0.78 | ESR2 (0.68) | ESR1ESR2KMT2ANOTUMNR1H2 | |
| SCHEMBL28675076 | 0.77 | TMEM97 (0.43) | ESR1ESR2NPC1KMT2ATMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |