Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.52 |
| ▸ | IDO1 | P14902 | 4/20 | 0.52 |
| ▸ | LDLR | P01130 | 1/20 | 0.45 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5966768 | 0.74 | CYP11B1 (0.52) | CYP11B1CYP11B2IDO1LDLRPCSK9 | |
| SCHEMBL16152320 | 0.74 | CYP11B1 (0.52) | CYP11B1CYP11B2IDO1LDLRPCSK9 | |
| SCHEMBL27794049 | 0.74 | CYP11B1 (0.52) | CYP11B1CYP11B2IDO1LDLRPCSK9 | |
| SCHEMBL12676744 | 0.74 | CYP11B1 (0.52) | CYP11B1CYP11B2IDO1LDLRPCSK9 | |
| SCHEMBL972964 | 0.74 | HPGDS (0.73) | CYP11B1CYP11B2IDO1LDLRPCSK9 | |
| SCHEMBL28785096 | 0.74 | CYP11B1 (0.56) | CYP11B1CYP11B2IDO1LDLRPCSK9 | |
| SCHEMBL12676747 | 0.72 | CYP11B1 (0.50) | CYP11B1CYP11B2IDO1LDLRPCSK9 | |
| SCHEMBL1951361 | 0.71 | CYP11B1 (0.62) | CYP11B1CYP11B2IDO1LDLRPCSK9 | |
| SCHEMBL23252453 | 0.70 | CYP11B1 (0.60) | CYP11B1CYP11B2IDO1LDLRPCSK9 | |
| SCHEMBL5324373 | 0.70 | CYP11B1 (0.60) | CYP11B1CYP11B2IDO1HPGDSL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041095-A1 | NOVEL TYROSINASE INHIBITORS, THEIR PROCESS OF PREPARATION AND THEIR USE IN HUMAN MEDICINE AND IN COSMETICS | Galderma Research & Development (FR) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008006824-A1 | NOVEL TYROSINASE INHIBITORS, THEIR PROCESS OF PREPARATION AND THEIR USE IN HUMAN MEDICINE AND IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-01-17 | — | — | WO | disclosed |