Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 2/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PRKX | P51817 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | MST1R | Q04912 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.39 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014598 | 0.91 | ABL1 (0.47) | CTSAABL1HPGDS | |
| SCHEMBL4012343 | 0.88 | CNR2 (0.44) | CTSAABL1P2RY12AVPR1B | |
| SCHEMBL2701916 | 0.86 | CTSA (0.45) | CTSADGAT2ROCK1PRKACAGSK3A | |
| SCHEMBL2704327 | 0.86 | CTSA (0.45) | CTSADGAT2ROCK1PRKACAGSK3A | |
| SCHEMBL4012466 | 0.83 | ABL1 (0.40) | ABL1P2RY12 | |
| SCHEMBL4012349 | 0.83 | ABL1 (0.40) | ABL1P2RY12 | |
| SCHEMBL4012642 | 0.82 | ABL1 (0.39) | ABL1P2RY12 | |
| SCHEMBL4016284 | 0.82 | ABL1 (0.39) | ABL1P2RY12 | |
| SCHEMBL4013441 | 0.81 | CCR1 (0.40) | CTSAROCK1ABL1P2RY12ROCK2 | |
| SCHEMBL2703783 | 0.77 | ABL1 (0.49) | CTSAABL1HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074096-A1 | 3-PYRIDINECARBOXAMIDE AND 2-PYRAZINECARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008040651-A1 | 3-PYRIDINECARBOXAMIDE AND 2-PYRAZINECARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-10 | — | — | WO | disclosed |