Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.44 |
| ▸ | CTSA | P10619 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | STK4 | Q13043 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012466 | 0.89 | ABL1 (0.40) | CNR2CNR1P2RY12ABL1CCR1 | |
| SCHEMBL4012349 | 0.89 | ABL1 (0.40) | CNR2CNR1P2RY12ABL1CCR1 | |
| SCHEMBL4011275 | 0.88 | CTSA (0.44) | CTSAP2RY12AVPR1BABL1 | |
| SCHEMBL4012642 | 0.87 | ABL1 (0.39) | CNR2CNR1TP53P2RY12ABL1 | |
| SCHEMBL4016284 | 0.87 | ABL1 (0.39) | CNR2CNR1TP53P2RY12ABL1 | |
| SCHEMBL2703736 | 0.86 | CNR2 (0.45) | CNR2CTSACNR1TP53STK4 | |
| SCHEMBL4014598 | 0.83 | ABL1 (0.47) | CTSACNR1ABL1KCNH2 | |
| SCHEMBL4013441 | 0.82 | CCR1 (0.40) | CTSATP53P2RY12ABL1CCR1 | |
| SCHEMBL2704238 | 0.76 | CNR1 (0.53) | CNR2CTSACNR1ABL1 | |
| SCHEMBL2701880 | 0.76 | CNR1 (0.53) | CNR2CTSACNR1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074096-A1 | 3-PYRIDINECARBOXAMIDE AND 2-PYRAZINECARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2009-07-01 | — | — | EP | claimed |
| WO-2008040651-A1 | 3-PYRIDINECARBOXAMIDE AND 2-PYRAZINECARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-10 | — | — | WO | claimed |