Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.41 |
| ▸ | USP2 | O75604 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5950347 | 1.00 | PDK2 (0.44) | PDK2CYP3A4MAPK1CYP2C19KMT2A | |
| SCHEMBL5950986 | 0.91 | SMN1; SMN2 (0.43) | MAPK1KMT2AMEN1USP2SMN1; SMN2 | |
| SCHEMBL4964668 | 0.88 | MAPT (0.47) | PDK2CYP3A4MAPK1CYP2C19KMT2A | |
| SCHEMBL4962318 | 0.88 | MAPT (0.47) | PDK2CYP3A4MAPK1CYP2C19KMT2A | |
| SCHEMBL4964952 | 0.83 | PDK2 (0.45) | PDK2CYP3A4MAPK1CYP2C19KMT2A | |
| SCHEMBL4964877 | 0.83 | PDK2 (0.45) | PDK2CYP3A4MAPK1CYP2C19KMT2A | |
| SCHEMBL4965635 | 0.79 | SMN1; SMN2 (0.46) | KMT2AMEN1SMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL4965152 | 0.76 | LMNA (0.43) | PDK2KMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6408605 | 0.76 | TDP1 (0.44) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4963030 | 0.76 | PDK2 (0.46) | PDK2MAPK1KMT2AMEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |