Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.53 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3334920 | 0.92 | CDC7 (0.58) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL4018765 | 0.92 | CDC7 (0.52) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3328062 | 0.90 | PIM1 (0.56) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3332263 | 0.90 | CDC7 (0.56) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3331277 | 0.90 | PIM1 (0.55) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3329022 | 0.89 | CDC7 (0.54) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3331548 | 0.89 | CDC7 (0.62) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3329763 | 0.88 | CDC7 (0.57) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3325796 | 0.87 | PIM1 (0.54) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3329414 | 0.86 | PIM1 (0.53) | CDC7PIM1CSNK2A2CLK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074103-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008133955-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | EXELIXIS, INC. (US) | 2008-11-06 | — | — | WO | claimed |
| EP-2074103-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008133955-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | EXELIXIS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |