Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.52 |
| ▸ | PIM1 | P11309 | 2/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3335075 | 0.93 | CDC7 (0.57) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL4011364 | 0.92 | CDC7 (0.53) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3327810 | 0.91 | CDC7 (0.55) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3329870 | 0.90 | PIM1 (0.54) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3325453 | 0.90 | CDC7 (0.59) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3331200 | 0.89 | CDC7 (0.53) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3330676 | 0.88 | CDC7 (0.56) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3334598 | 0.88 | PIM1 (0.53) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3334155 | 0.87 | CDC7 (0.52) | CDC7PIM1CSNK2A2CLK1GSK3B | |
| SCHEMBL3330950 | 0.87 | CDC7 (0.54) | CDC7PIM1CSNK2A2CLK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074103-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008133955-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | EXELIXIS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |