Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 16/20 | 0.75 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.56 |
| ▸ | PRKDC | P78527 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009204 | 0.92 | ATR (0.67) | ATRPRKDCATMEGFR | |
| SCHEMBL4016014 | 0.91 | ATR (0.66) | ATRPRKDCATMEGFR | |
| SCHEMBL13139379 | 0.89 | ATR (0.70) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL4003249 | 0.89 | ATR (0.64) | ATRPRKDCATMEGFR | |
| SCHEMBL4009691 | 0.89 | ATR (0.72) | ATRPRKDCATMEGFR | |
| SCHEMBL4009550 | 0.89 | ATR (0.72) | ATRPRKDCATMEGFR | |
| SCHEMBL4008991 | 0.89 | ATR (0.60) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL3058004 | 0.85 | ATR (1.00) | ATRCDK1CDK2MKNK1MKNK2 | |
| SCHEMBL4039257 | 0.83 | ATR (0.80) | ATRPRKDCATMEGFR | |
| Hydrochloric Acid SCHEMBL3511276 | 0.81 | HTR7 (0.57) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |