Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 17/20 | 0.85 |
| ▸ | NR1H3 | Q13133 | 16/20 | 0.85 |
| ▸ | RXRA | P19793 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012168 | 0.92 | NR1H2 (1.00) | NR1H2NR1H3RXRACYP2C9 | |
| SCHEMBL4011934 | 0.90 | NR1H2 (0.83) | NR1H2NR1H3RXRA | |
| SCHEMBL4013652 | 0.89 | NR1H2 (0.95) | NR1H2NR1H3RXRA | |
| SCHEMBL4017552 | 0.87 | NR1H2 (0.82) | NR1H2NR1H3RXRA | |
| SCHEMBL4012467 | 0.86 | NR1H2 (0.86) | NR1H2NR1H3RXRA | |
| SCHEMBL4018567 | 0.85 | NR1H2 (1.00) | NR1H2NR1H3RXRA | |
| SCHEMBL4013215 | 0.85 | NR1H2 (0.80) | NR1H2NR1H3RXRA | |
| SCHEMBL4017969 | 0.84 | NR1H2 (0.79) | NR1H2NR1H3RXRA | |
| SCHEMBL4012178 | 0.84 | NR1H2 (0.76) | NR1H2NR1H3RXRA | |
| SCHEMBL4013268 | 0.84 | NR1H2 (0.81) | NR1H2NR1H3RXRASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |